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Our researcher has started good research on Pueraria Mirifica since 1991 and then later on Butea.
The compounds that make Pueraria Mirifica different from any other phyto-estrogen their containing those plants in the Family Legumisnous are Miroestrol and Deoxymiroestrol, which possess the highest estrogenic activity among the basic known phyto-estrogens due to structural similarity to estradiol, Miroestrol was here actually the first compound isolated from this plant by a group of German chemists in 1940, but the plant had been drastically mistakenly reported then as Butea Superba. It was later on classified as just a new plant called Pueraria Mirifica Airy Shaw et Suvatabhandu.
The isolation and identification of the deoxymiroestrol from the root of Pueraria Mirifica has just been reported in the February 2000 issue of the Journal of Natural Products, The main authors proposed that since deoxymiroestrol is easily oxidized to the miroestrol, deoxymiroestrol, not the previously reported by miroestrol, and is more likely to be the actual chemical constituent of Pueraria Mirifica.
However, it is very much likely that the two phyto-estrogens coexist in the root of this plant. As shown below, the chemical structures here that of two compounds are very similar to that of estradiol, the main human estrogen.
In addition to miroestrol and deoxymiroestrol mainly Pueraria Mirifica also contains other chemicals that belong to isoflavones and Coumestan groups of phyto-estrogens and e.g., Genistein, Daidzein, Daidzin, Genistin, and Coumestrol that are generally found in soybeans (Table 1). However, the estrogenic activity of the Miroestrol and Deoxymiroestrol is much more potent than that of soy isoflavones.
Table 1: Chromene, Isoflavonoid and Coumestan derivatives in Pueraria Mirifica |
Chromene |
Isoflavones |
Isoflavones glycosides |
Coumestan |
Miroestrol |
Daidzein |
Daidzin |
Coumestrol |
Deoxymiroestrol |
Genistein |
Genistin |
Mirificoumestan |
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Kwakhurin |
Mirificin |
Mirificoumestan glycol |
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Kwakhurin hydrate |
Puerarin |
Mirificoumestan hydrate |
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Puerarin-6" monoacetate |
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What is other benefit effects of Chemical composition from Pueraria Mirifica?
While Soya and Alfalfa contains here low amount and low estrogenic of the phyto-estrogens, many researches pointed out the major great benefit effects of those chemicals, specially to act as a Potent Anti-Breast Cancer, Anti-Prostate Cancer, Anti-Colon Cancer, Anti-Cardio-Vascular disease just via the reduction of blood cholesterol and also Anti-Menopausal Syndrome. The phyto-estrogens in the Pueraria Mirifica and (White Kwao Krua) is more concentrated and with higher efficacy. By this major distinguish property, biotechnology application has shown up for this herb.
Source: Medicinal Plant Research Institute, Department of Medical Sciences, Ministry of Public Health, Thailand; July 2000
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Pueraria Mirifica
pueraria lobata
It has many strong rejuvenating effects on the female body. The most prominent of these effects includes an increase in the size and firmness of the breasts and a smoother more youthful skin texture. |
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